Industrialization, besides being a boon to mankind has however caused certain amounts of instability in terms of human health and disease prevalence. Allergic reactions remain the most poorly damaged health condition owing to overt exposure to chemicals and fumes. Work allergies still remain a daunting health hazard, invoking unparalleled advances in drug formulation and therapy. To achieve this, adoption of rodents such as humanized mouse and rats witness large scale adoption for several clinical studies. Advantages of humanized mouse and rats such as small and manageable size, low cost maintenance and the presence of inbred strains collectively make these rodents integral for biomedical research.
Recent researches are directed to offer greater understanding on developing advanced humanized mice and rat models aided by machine learning capabilities that are used to understand novel disease breakthroughs in humans, earlier spotted in mice. The development is likely to aid in advancing studies on new disease probabilities in humans in addition to already existing ones.
Humanized Mouse and Rat Models Gaining Massive Adoption in ART (Assisted Reproductive Technology)
Mice and rats continue to remain preferred models for biomedical research owing to large scale availability of inbred strains that consistently deliver genetically superior animals as opposed to outbred ones, thus offering superlative genetic uniformity which is crucial for any biomedical research. Genetic engineering now is also applied in conjunction with ARTS assisted reproductive sciences owing to their stark similarities that make scientific studies result driven. Owing to large scale prevalence of reproduction challenges such as delayed pregnancies and unsuccessful pregnancies, artificial reproductive is gaining ample momentum in recent years, and so are the R&D advances in assisted reproductive technologies.
Animal models such as humanized mouse and rats have long been banked upon as dependable aids to decode complexities in reproduction, pertaining to ovarian malfunction and fertility disorders. Humanized mouse and rat models are used to study the common birth defects observed in ART pregnancies which are most often minor but are very common.
Advances in animal modelling with advanced technologies such as next generation sequencing, genome engineering as well as machine learning and big data render in improved humanized mouse and rat model development. Mice and rats till now remain the most preferred lab animals to study human disorders accurately. Advances in combinational drugs and precision medicine in the wake of hard to heal disorders such as cancers and AIDS have propelled further adoption spurt of humanized mouse and rat models. Advances in nuclease based genetic engineering have significantly lent momentum to the adoption of humanized mouse and rat models for decoding human diseases.